Phone: (787) 832-4040 Ext. 2585

Email: madeline@ece.uprm.edu

Office: IQ-104-D

Office Hours:

Website(s):

Lab(s):IQ-101-A

Field(s):Biochemical, Biomedical, Nanomaterials, Polymers

Current Course(s):

Curriculum Vitae:

  • Purdue University:  Doctor of Philosophy in Chemical Engineering, August 2001
  • Purdue University:  Masters of Science in Chemical Engineering, May 1999
  • University of Puerto Rico, Mayagüez Campus, Bachelor of Science in Chemical Engineering, May 1997
  • INQU4011 Chemical Engineering Thermodynamics
  • INQU4012 Chemical Engineering Thermodynamics II
  • INQU4016 Plastics Technology
  • INQU8027 Engineering Principles Applied To Drug Therapy
  • Nanomaterials For Biomedical Applications
  • Translational Medical Research
  • Applications Of Materials For Biomedical Applications
  • Alvarez-Berrios M.P., Castillo, A., Rinaldi, C., Torres-Lugo, M., Enhanced proteotoxic stress: one of the contributors for hyperthermic potentiation of the proteasome inhibitor bortezomib using magnetic nanoparticles, Biomat. Sci., 3, 2015, 391 – 400, DOI: 10.1039/C4BM00223
  • Gavira, J.A, Cera-Manjarres, A., Ortiz, K., Mendes, Jimenez-Torres, J.A., Patiño-Lopez, L.D. Torres-Lugo, M, Use of Cross-Linked Poly(ethylene glycol)-Based Hydrogels for Protein Crystallization, Cryst. Growth. Des., 14(7), 3239-3248, 2014, PMC421591
  • Alvarez-Berrios, M., Castillo, A., Rinaldi, C., Torres-Lugo, M., Magnetic Fluid hyperthermia Enhances Bortezomib Cytotoxicity in Sensitive and Resistant Cancer Cell Lines, Int. J. Nanomed., 9(1), 145-153, 2014.
  • Torres-Lugo, M., Rinaldi, C., Thermal Potentiation of Chemotherapy by Magnetic Nanoparticles, Nanomedicine, Nanomedicine, 8(10), 1689-1707, 2013.
  • Ayala V., Herrera, A.P., Latorre-Esteves, M., Torres-Lugo, M., Rinaldi, C., Effect of Surface Charge on the Colloidal Stability and In Vitro Uptake of Carboxymethyl Dextran-Coated Iron Oxide Nanoparticles, J. Nanopart. Res., 15, 1874-1888, 2013
  • Domenech, M., Marrero I., Torres-Lugo, M. Carlos Rinaldi, Lysosomal Membrane Permeabilization by Targeted Magnetic Nanoparticles in Alternating Magnetic Fields, ACS Nano, 7(6), 5091-5101, 2013
  • Santiago-Rodriguez, L., Montalvo-Lafontaine, M. Castro, C., Mendez, J., Juan, E., La Torre-Esteves, M., Mora, E., Torres-Lugo, M., Rinaldi, C., Synthesis, Stability, Cellular Upatake, and Blood Circulation Time of Carboxymethyl Inulin Coated Magnetic Nanoparticles, J. Mater. Chem., 1, 2807-2817, 2013.
  • Guillermo N. Armaiz-Pena, Rebecca L. Stone, Yvonne G. Lin, Liz Y. Han, Alpa M. Nick, Lingegowda S. Mangala, Julie K. Allen, Gabriel J. Villares, Anthony Cruz, Pablo Vivas-Mejias, Zheng Wu, Robert D. English, Kizhake V. Soman, Mian M.K. Shazhad, Michael T. Deavers, Alexander Zien, David B. Jackson, John E. Wiktorowicz, Madeline Torres-Lugo, Gustavo E. Lopez, Gary E. Gallick, Koen De Geest1, Menashe Bar-Eli, Gabriel Lopez-Berestein, Steve W. Cole, Susan K. Lutgendorf and Anil K. Sood, Src activation by ?-adrenoreceptors is a key switch for tumour metastasis, Nat. Comm., 4, 1403, 2013.
  • Alvarez-Berrios, M.P., Castillo, A., Mendez, J., Soto, O., Rinaldi, C., Torres-Lugo, M., Hyperthermic Potentiation of Cisplatin by Magnetic Nanoparticle Heaters is Correlated with an Increase in Cell Membrane Fluidity, Int., J., Nanomed., 8, 1003-1013, 2013.
  • Court,K.A., Jerez,J.,Romañach ,R., Torres-Lugo, M., Particle Encapsulation in Crosslinked Hydrogel Systems: Distribution and Optimization, J. Mater. Sci. Eng. A&B, 2(10): 539-550,2012.
  • López, G.E., Cruz, A., Sepulveda-Chervony, M., Lopez-Garriga, J., Torres-Lugo, M., Using a reduced dimensionality model to compute the thermodynamic properties of dimeric polypeptides systems aggregates, J. Biol. Phys., 38(3): 383-395, 2012.
  • Creixell, M., Bohorquez, A., Torres-Lugo, M., Rinaldi, C., EGFR-targeted magnetic nanoparticle heaters can kill cancer cells without a perceptible temperature rise, Nano Letters, 5(9): 7124-7129, 2011
  • Lee, J.S, Rodríguez-Luccioni, H, Méndez, J., Sood A.K, Rianldi, C., Torres-Lugo, M., Hyperthermia Induced by Magnetic Nanoparticles Improves the Effectiveness of the Anticancer Drug cis-Diamminedichloroplatinum, J. Nanosci. Nanotech, 11(5):4153-4157, 2011
  • Rodríguez-Luccioni, H., Latorre-Esteves, M., Méndez, J., Soto, O., Rodríguez, A., Rinaldi, C., Torres-Lugo, M., Enhanced Reduction in Cell Viability by Hyperthermia Using Magnetic Nanoparticles, Int. J. Nanomed., 6:373-380, 2011.
  • Creixell, M., Herrera, Adriana, P., Latorre-Esteves, M., Ayala, V., Torres-Lugo, Madeline, Rinaldi, C., The effect of grafting method on the colloidal stability and in vitro cytotoxicity of carboxymethyl dextran coated magnetic nanoparticles, J. Mater. Chem, 20(39): 8539-8547, 2010.
  • M. Creixell, A.P. Herrera, V. Ayala, M. Latorre-Esteves, M. Perez-Torres, M. Torres-Lugo, and C. Rinaldi, Preparation of EGF conjugated magnetic nanoparticles and their internalization into EGFR overexpressing cancer cells, J. Mag. and Magn. Mater., 322(15):2244-2250, 2011
  • Hernández,R., Méndez, J., Lamboy, J., Torres-Lugo, M., Roman, F.R., Melendez, E., Titanium(IV) Complexes : Cytotoxicity and Cellular Uptake of Titanium(IV) Complexes on Caco-2 Cell Line, Toxicology in Vitro, 24(1),178-183 , 2010.